Tolerability/Safety of Intranasal AZD8848 in Healthy Male Volunteers and Seasonal Allergic Rhinitis Male Patients Out of Season

Inclusion Criteria: * History of birch and/or timothy grass pollen induced seasonal allergic rhinitis for at least the previous 2 years * Body mass index (BMI) between 19 and 30 kg/ m2 and a weight between 50 and 100 kg * No clinically relevant abnormal findings Exclusion Criteria: * Acute illness which requires medical intervention * Definite or suspected personal history of adverse drug reactions or drug hypersensitivity * Clinical relevant disease or disorder (past or present) * A history of asthma