The purpose of the Study is to determine whether early treatment with pravastatin can reduce adverse cardiac events in patients with acute myocardial infarction and minimally to mildly elevated serum Low Density Lipoprotein -Cholesterol (LDL-C) levels.
The investigators previously reported the beneficial effect of early use of low-dose pravastatin on major adverse cardiac events in patients with acute myocardial infarction and mild to moderate hypercholesterolemia in the OACIS-LIPID Study. The PRACTIC study is designed as the OACIS-LIPID II trial to determine whether early treatment with pravastatin can reduce adverse cardiac events in patients with acute myocardial infarction and minimally to mildly elevated serum Low Density Lipoprotein -Cholesterol (LDL-C) levels.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
400
Take an initial dose of pravastatin to start as 10mg/day, which is the recommended initial dose by Health, Labour and Welfare Ministry of Japan, and a diet counseling.
Kansai Rosai Hospital
Amagasaki, Hyōgo, Japan
RECRUITINGHigashi-Osaka City General Hospital
Higashiosaka, Osaka, Japan
RECRUITINGKawachi General Hospital
Higashiosaka, Osaka, Japan
Combination of death, non-fatal myocardial infarction, unstable angina, coronary revascularization (except anticipated revascularization before randomization), non-fatal stroke and re-hospitalization due to heart failure or other cardiac causes.
Time frame: 20, 50 and 80% of the projected number of patients have been enrolled in the study
Each component of the primary outcome measures.
Time frame: 20, 50 and 80% of the projected number of patients have been enrolled in the study
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Osaka Minami Medical Center, National Hospital Organization
Kawachi-Nagano, Osaka, Japan
RECRUITINGOsaka General Medical Center
Osaka, Osaka, Japan
NOT_YET_RECRUITINGOsaka Police Hospital
Osaka, Osaka, Japan
RECRUITINGSakurabashi Watanabe Hospital
Osaka, Osaka, Japan
NOT_YET_RECRUITINGOsaka Rosai Hospital
Sakai, Osaka, Japan
RECRUITINGOsaka University Hospital
Suita, Osaka, Japan
RECRUITING