A Safety/Tolerability and Pharmakokinetic Study of Sargramostim Administrated in the Gingiva

Inclusion Criteria: * Healthy individuals (male or female) referred to Dept of Oral \& Maxillofacial surgery to have a lower wisdom tooth surgically extracted * ≥ 20 and ≤ 40 years of age * Analysis results of blood status within normal reference ranges * Ability to attend the scheduled visits for evaluation procedures * Women with child-bearing potential: use of an adequate method of contraception to avoid pregnancy throughout the study * Signed informed consent Exclusion Criteria: * Any significant disease (acute or chronic) or any medication with concomitant oral manifestations that in the opinion of the investigator would interfere with safety evaluation of Leukine. * An active osseous infection or periodontal infection, any active mucosal lesions or a history of acute necrotizing ulcerative gingivitis. * Current use of anti-coagulant therapy or within 10 days from baseline * Current use of immunomodulating medication * Current use of corticosteroids (Amendment 1: topical use permitted). * Current use of lithium. * Use of tobacco products or nicotine replacement therapy * Alcohol or drug abuse * HIV or hepatitis infection * Pregnancy or lactation * Participation in another clinical study on medicinal products at the time of inclusion * Lack of suitability for participation in the trial, for any reason, as judged by the Investigator.