Pilot Study of Curcumin Formulation and Ashwagandha Extract in Advanced Osteosarcoma

Inclusion Criteria: * Patients (between the ages of 8 to 65 years) with histologically proven high grade osteosarcoma of the extremity and relapsed disease after primary line of treatment who are unsuitable or refuse secondary chemotherapy. * Patients with advanced disease unable or unwilling to take primary conventional treatment * Patients with early or non-metastatic disease who are unable or unwilling to take the standard chemotherapy. * Adequate hepatic function defined by total bilirubin not more than 1.5 times the upper limit of normal (ULN) and SGOT and SGPT not more than 2.5 times the (ULN) * Adequate renal function defined by the creatinine clearance greater than 50 ml/min, calculated by cockcroft-Gault formula Exclusion Criteria: * Patients who are suitable for second line chemotherapy and can afford it * Age less than 8 years or greater than 65 years * Pregnant or lactating women * Patients who are unable or unwilling to provide blood samples for the drug assays. * Low grade osteosarcoma * Patient requiring treatment with CYP3A4 inducers or inhibitors (patients on treatment for epilepsy or tuberculosis) * Participation in any investigational drug study within 28 days prior to study treatment.