To Study the Absorption, Distribution, Metabolism and Excretion of AZD1305

AstraZeneca10 enrolled

Overview

The purpose of this study is to learn more about how AZD1305 is handled by the body, i.e the absorption, distribution, metabolism and excretion of AZD1305.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

AZD1305DRUG

oral solution, single dose

AZD1305DRUG

iv infusion, single dose

Eligibility

Sex: MALEMin age: 35 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers * A body mass index (BMI=weight/height2) of 19 to 30 kg/m2 Exclusion Criteria: * Potassium outside normal reference values * ECG findings outside normal range

Locations (1)

Research Site

Macclesfield, Cheshire, United Kingdom

Outcomes

Primary Outcomes

Pharmacokinetic variables

Time frame: During all dosing visits

Secondary Outcomes

Adverse events, vital signs, ECG, laboratory variables and physical examination

Time frame: During the study

Data from ClinicalTrials.gov

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