Study to Investigate the Safety, Tolerability and Pharmacokinetics of AZD1386

Inclusion Criteria: * Healthy Caucasians, males or females aged ≥20 and ≤ 45 years or between 65 80 years. Female subjects must be surgically sterile or post-menopausal for at least 12 months prior to the enrolment visit. * Body Mass Index (BMI) of ≥18 to ≤ 30 kg/m2 and weight of ≥50 to ≤100 kg * Clinically normal physical findings including heart rate \> 45 bpm and laboratory values and normal resting ECG Exclusion Criteria: * History of somatic or psychiatric disease/condition, which may interfere with the objectives of the study. * History of severe allergy/hypersensitivity or symptoms/signs of ongoing allergy/hypersensitivity. * Subjects with a high decrease in blood pressure within 5 minutes when going from a supine to standing position.