A Multi-center Study of Spherule-Derived Coccidioidin

Inclusion Criteria: * Good Health (absence of active medical disease) * Meets criteria specific to population groups: * Coccidioidomycosis Group: * History of coccidioidomycosis of at least 45 days duration confirmed by roentgenograph serologic or mycologic findings * Histoplasmosis Group: * History of pulmonary histoplasmosis * Naive Control Group: * Lifetime residence in the states of WA, OR, ID, or MT * Never employed as an agricultural worker * Serology negative for C.immitis antibodies Exclusion Criteria (All Groups): * Active medical disease * Alcohol abuse or illicit drug use * Influenza-like illness within the past 4 weeks * Immunizations within the past 4 weeks * Current atopic or contact dermatitis, psoriasis, erythema nodosum, urticaria * Current treatment with corticosteroids, cytotoxic or immunosuppressive drugs * Immunodeficiency disease * HIV infection * Previous skin test with coccidioidin or SD Coccidioidin * Pregnant or lactating * Adverse reaction to thimerosal * Adverse reaction to Candida or Trichophyton skin test antigens Coccidioidomycosis Group: * Current cavitary or disseminated coccidioidomycosis * History of histoplasmosis, or blastomycosis Histoplasmosis Group: * History of coccidioidomycosis or blastomycosis Naive Control Group: * History of coccidioidomycosis, histoplasmosis, blastomycosis * Travel for more than 30 days in designated areas of CA, AZ, NV, UT, NM, TX and Mexico, Central and South America. Travel for more than 7 days in restricted areas of CA, AZ and TX.