Study of TRC102 in Combination With Pemetrexed in Cancer Patients

Inclusion Criteria: * The patient has given informed consent * The patient is willing and able to abide by the protocol * The patient has cancer and curative therapy is unavailable or standard therapy has failed * The patient is at least 18 years of age * The patient has adequate ability to perform activities of daily living * The patient has recovered from significant toxicities of previous therapy * The patient has adequate organ function as assessed by laboratory testing Exclusion Criteria: * The patient has had prior treatment with high-dose chemotherapy requiring stem cell rescue * The patient is currently on treatment on another therapeutic clinical trial or has received an investigational drug within 4 weeks prior to first dose on this study * The patient has had prior surgery, radiation or systemic therapy within 4 weeks of starting the study * The patient has a history of CNS cancer * The patient has an unstable medical condition including (not limited to) cardiac disease, HIV/AIDS, history of stroke, hepatitis or significant paricardial, pleural or peritoneal effusion * The patient is pregnant or breastfeeding