Effect of Amlodipine Monotherapy or Combined With Terazosin on Lower Urinary Tract Symptoms and Hypertension

Anhui Medical University360 enrolled

Overview

The aim of this study was to investigate the efficacy and safety of low dose amlodipine alone, or combined with low dose terazosin in male patients with both lower urinary tract symptoms and hypertension.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

360

Conditions

Lower Urinary Tract Symptoms Hypertension

Interventions

amlodipineDRUG

amlodipine 5mg once daily for 28 days

terazosinDRUG

terazosin 2 mg once daily for 28 days

amlodipine plus terazosinDRUG

amlodipine 5 mg plus terazosin 2 mg once daily for 28days

Eligibility

Sex: MALEMin age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Men 50 years or older 2. with LUTS \[defined as International Prostate Symptom Score (IPSS) \>= 10\]. 3. Stage 1 or 2 essential hypertension (SBP \>= 140 mm Hg and \< 180 mm Hg and/or DBP \>= 90 mm Hg and \< 110 mm Hg) Exclusion Criteria: 1. A history of postural hypotension 2. Secondary hypertension 3. Prostate cancer 4. Prostate surgery or other intervention 5. Use of any agents to influence the LUTS symptoms in the last 4 weeks 6. Other severe diseases

Locations (1)

Biomedicine Inistitute of Anhui Medical University

Hefei, Anhui, China

Outcomes

Primary Outcomes

The primary efficacy outcomes were reductions in blood pressure and International Prostate Symptoms Score (IPSS) and sub-scores.

Time frame: 28th day after treatment

Data from ClinicalTrials.gov

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