RATIONALE: Gathering information about allergies to metals may help doctors learn whether having an allergy to metal used in dental work increases the risk of developing oral cancer. PURPOSE: This clinical trial is studying contact allergies to dental metal as a possible risk factor for oral cancer.
OBJECTIVES: * Identify the relationship between intraoral metal contact allergy and epithelial carcinogenesis in patients with newly or previously diagnosed intraoral squamous cell carcinoma. * Compare the prevalence of metal contact allergy in these patients with control data from other existing study populations. OUTLINE: This is a multicenter study. * Participants undergo metal patch testing using 27 metals\* commonly used in dental repairs that are part of the Mayo metal series. Metal patches are applied to the patient's back for 3 days and the back is read on days 3 and 5. Relevant patient data obtained from their medical and dental history, physical exam, laboratory values and treatment are documented. NOTE: \*Healthy volunteers (control) undergo metal patch testing using 8 metals most commonly positive for contact allergens.
Study Type
OBSERVATIONAL
Enrollment
115
Twenty - seven (27) metal patch tests will be applied to the patient's back and left in place for 3 days
Mayo Clinic
Rochester, Minnesota, United States
Relationship between intraoral metal contact allergy and epithelial carcinogenesis
Time frame: one year
Prevalence of metal contact allergy comparison to study control data
Time frame: one year
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