Comparative Study of the Efficacy of SARNA Sensitive Lotion for Treatment of Uremic Itch in Adult Hemodialysis Patients

Inclusion Criteria: * Male or female patients 18 years of age to 70 years of age. * A diagnosis of moderate to severe pruritus. * At least 3 episodes of itch over a period of 2 weeks, each lasting for 2 minutes or more. * Symptoms of itch in regular pattern over 6 months. * Itch Visual analog scale (VAS) of 3cm or more out of 10 cm. * All subjects will be end stage renal failure patients undergoing hemodialysis for at least 3 months, who have substantial pruritus for more than 6 months. Substantial pruritus is defined as persistent pruritus impairing sleep or daytime activity. * Ability and willingness to follow all study procedures, attend all scheduled visits, and successfully complete the study * The ability to understand and sign a written informed consent form, which must be obtained prior to treatment. Exclusion Criteria: * Presence of infection (as defined by the investigator) on the area to be treated. * Subjects with history of pruritus predating renal failure and subjects with skin disease unrelated to uremia, such as atopic dermatitis, will be excluded. * Use of systemic medications for treatment of pruritus including corticosteroids within the past 4 weeks and during the study. * Use of topical medications for treatment of pruritus, including corticosteroids, within the past week. * Pregnant women, women who are breast feeding, or women of child bearing potential who are not practicing an acceptable method of birth control (abstinence, birth control pill/patch, barrier with spermicidal jelly, IUD, etc.), as determined by the investigator. Acceptable contraception must be used during the entire study.