The aim of the study is to evaluate the efficacy of Voluven® in the prevention of maternal hypotension in women undergoing spinal anesthesia for cesarean section
Intravenous fluid administration prior to spinal anesthesia for cesarean section is an established part of anesthetic practice for the prevention of maternal hypotension. Systematic reviews of clinical data suggest the usefulness of administering colloids to decrease the incidence of hypotension This study will compare the clinical efficacy and safety of HES 130/0.4 (6%) in normal saline vs. Ringer's lactate solution in prevention of hypotension during spinal anesthesia for elective cesarean section.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
167
500 mL of HES 130/0.4 (6%) and 500 mL Ringer's Lactate Solution
1000 mL Ringer's Lactate solution
CHU Clermont Ferrand - Hotel Dieu, Service Anesthesie-Reanimation
Clermont-Ferrand, France
Höpital Louis-Mourier - Service d'Anesthesie
Colombes, France
Incidence of hypotension
Time frame: Time between induction of spinal anesthesia until delivery
Minimum of systolic blood pressure until delivery
Time frame: between induction of anesthesia and delivery
Maternal heart rate between induction of anesthesia and delivery
Time frame: between induction of anesthesia and delivery
Onset and duration of hypotension between induction of anesthesia and delivery
Time frame: between induction of anesthesia and delivery
Phenylephrine requirements to keep systolic blood pressure equal or higher than 95% of baseline value
Time frame: between induction of anesthesia and delivery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Département d'Anesthésie-Réanimation - Centre Hospitalo-Universitaire de Bicêtre
Le Kremlin-Bicêtre, France
Hopital Jeanne de Flandre, CHU
Lille, France
CHU Hotel Dieu, Service Anesthesie
Lyon, France
Hopital Arnaud de Villeneuve - Service Anesthésie-Réanimation
Montpellier, France
Hopital de l'Archet, Service Anesthesie-Reanimation
Nice, France
Hopital Caremeau, CHU, Service Anesthesie
Nîmes, France
Hopital Cochin, Service Anesthesie-Reanimation Chirurgicale
Paris, France
Hôpital Armand-Trousseau, Service d'anesthésie-réanimation
Paris, France
...and 4 more locations