Intrathecal Morphine in Knee Arthroplasty

University College Hospital Galway60 enrolled

Overview

This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement.We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Pain, Postoperative Arthroplasty, Replacement, Knee

Interventions

intra thecal morphineDRUG

100 mcg intrathecal morphine given once .

intra thecal morphineDRUG

200 mcg intrathecal morphine given once

intra thecal morphineDRUG

300 mcg intrathecal morphine given once

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients for elective total knee arthroplasty Exclusion Criteria: * No contraindication to spinal * No allergy to morphine, rescue analgesia or anti-emesis treatment.

Outcomes

Primary Outcomes

pain

Time frame: 24 hours

Secondary Outcomes

nausea and vomiting

Time frame: 24 hours

pruritus

Time frame: 24 hours

sedation

Time frame: 24 hours

Data from ClinicalTrials.gov

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