An Imaging Study in Patients With Atherosclerosis Taking Rilapladib or Placebo for 12 Weeks

Inclusion Criteria: * Capable of giving written informed consent and able to understand and comply with protocol requirements, instructions and protocol-stated restrictions. * Male or female, aged 50 to 80 years inclusive, at screening. * Females must be of non-childbearing potential * Body weight ≥ 50 kg and BMI within the range 19-35 kg/m2 * Documented atherosclerotic vascular disease (e.g. prior MI, prior revascularization, peripheral arterial disease, carotid disease, or cerebrovascular disease) and clinically stable for at least 6 months * If diabetic, have well controlled diabetes, defined for the purpose of this study as HbA1c ≤8% or FPG ≤200 mg/dL * Evidence of plaque inflammation \[carotid artery or ascending aorta plaque inflammation defined as a tissue to background ratio (TBR) ≥ 1.6\] * On a stable dose of a statin for 3 months prior to screening with no evidence of statin intolerance Exclusion Criteria: * Recent (i.e., \<6 months from Screening Visit) CV event defined as ST-elevation MI or non-ST-elevation MI, confirmed by cardiac enzyme elevation and ECG changes, coronary revascularization (PCI or CABG), stroke of any etiology, resuscitated sudden death, prior carotid surgery or stenting procedure * Evidence of clinical instability or abnormal clinical laboratory findings prior to randomization that, in the opinion of the Investigator, makes the subject unsuitable for the study. * Exposure to substantial radiation within the past 12 months * Planned cardiac surgery (e.g., CABG, valve repair or replacement, or aneurysmectomy), PCI or major non-cardiac surgery within the study period * Current inadequately controlled hypertension (blood pressure ≥160 mmHg systolic or ≥100 mmHg diastolic) on a stable dose of anti-hypertensive medication * Diabetics taking injectable insulin at screening * Serum triglycerides \>400 mg/dL, LDLc \>130 mg/dL * Recent (\<1 month) or ongoing acute infection. * History of chronic inflammatory disease * Recently received (\<1 month) or currently receiving oral or injectable corticosteroids, or regular use of nasal, inhaled or topical corticosteroids. * Subjects who will commence, or who are likely to commence regular treatment with oral, non-steroidal anti-inflammatory drugs (NSAIDs) from screening until study completion * Currently receiving oral or injectable potent CYP3A4 inhibitor(s) * History of chronic viral hepatitis or other chronic hepatic disorders; or ALT or AST \>1.5 x ULN, or alkaline phosphatase or total bilirubin \>1.5 x ULN of laboratory reference range at Screen * Renal impairment with serum creatinine \>2.0 mg/dl or history of kidney transplant or status post nephrectomy. * History of myopathy or inflammatory muscle disease, or elevated total CPK at screening * History of severe heart failure defined as NYHA class III or IV or those with known severe left ventricular dysfunction (ejection fraction\<30%) regardless of symptomatic status * History of adult asthma (or reactive airway disease) manifested by bronchospasm in the past 6 months, or currently taking regular anti-asthmatic medication(s) * History of anaphylaxis, anaphylactoid (resembling anaphylaxis) reactions or severe allergic responses * History of malignancy within the past 2 years. * A history of glaucoma or any other findings in the baseline eye exam * Current life-threatening condition other than vascular disease that may prevent a subject from completing the study * QTc interval ≥450msec at screening or ≥480 msec for subjects with bundle branch block * History of drug abuse within the past 6 months * Previous exposure to rilapladib. * Contraindication to MRI scanning * Use of an investigational drug within 30 days or 5 half-lives (whichever is the longer) preceding the first dose of study medication * Any other subject the Investigator deems unsuitable for the study