Intestinal pathogenes are often involved in postoperative complications after colon surgery. Probiotic bacteria, i e live bacteria which have beneficial effects on the host when ingested, have been shown to reduce bacterial translocation in animal studies. However, in humans studies results have varied. The purpose with this study was to find whether high doses of Lactobacillus plantarum 299v affects the potentially pathogenic microflora of the gut, bacterial translocation and cell proliferation in patients undergoing planned colon surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
72
Bacteria in a concentration of 10(9) CFU/ml
Oatmeal drink as in arm 1 but without bacteria added.
Dept of Surgery, Malmö University Hospital
Malmo, Sweden
Change in intestinal bacterial microflora
Time frame: Before inclusion, after treatment, during surgery, postoperative day 6, 6 weeks, 6 months
Bacterial translocation
Time frame: During surgery
Inflammatory response (cytokines)
Time frame: Preoperative, during operation, 3, 24 an 48 hours postoperastive
Cell proliferation
Time frame: During surgery
Postoperative complications
Time frame: One week after surgery
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