Does Intravenous Cannabis Reduce Postoperative Nausea and Vomiting (PONV)?

Insel Gruppe AG, University Hospital Bern320 enrolled

Overview

The investigators evaluate if intravenously applied THC (Cannabis) reduces postoperative Nausea and vomiting. THC will be given during anesthesia before emergence. We measure how long and how effective it reduces PONV

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

320

Conditions

Nausea Vomiting

Interventions

THC 9-d-tetra hydro cannabinolDRUG

0.125mg/kg iv one time

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA I-III * elective open and laparoscopic surgery \>1hour Exclusion Criteria: * ambulatory surgery * pregnancy, breast feeding * \>ASA III * BMI \>35 * antipsychotic, antiemetic, cytostatic therapy * major cardiovascular, renal, hepatic, central nervous system disease * current chronic cannabis consumption and hard drug abuse * schizophrenia * preoperative nausea and vomiting, vestibular disease * not speaking german or french * refusal to participate

Locations (1)

Inselspital, Bern University Hospital

Bern, Canton of Bern, Switzerland

Outcomes

Primary Outcomes

Absence of postoperative Nausea and Vomiting

Time frame: 0-24h after Operation

Secondary Outcomes

Psychological and physiological data after ingestion of THC Analgetics required

Time frame: 0-24h after operation

Data from ClinicalTrials.gov

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