Repeated High-dose Inhaled Corticosteroids for Asthma

Inclusion criteria: * Physician diagnosis of asthma. * Age ≥18 years and ≤50 years * Evidence of airflow obstruction as measured by spirometry and flow-volume loop per American Thoracic Society guidelines. * Treatment for asthma with: * daily inhaled corticosteroids and long-acting beta2-agonists, AND * as-needed use of a short-acting beta2-agonist Exclusion criteria: * History of \>10 pack-year tobacco use * Other pulmonary or cardiac diagnosis that is actively being treated * History of adverse events or allergy to fluticasone * Systemic corticosteroid therapy within 7 days of study visit * Inability to obtain written informed consent