Mesalazine Granules vs. Placebo for the Prevention of Recurrence of Diverticulitis

Inclusion Criteria: * Diagnosis of left-sided uncomplicated diverticular disease confirmed by ultrasonography or computed tomography * Presence of at least one diverticulum of the left colon * Most recent attack of left-sided uncomplicated diverticulitis responding to antibiotics and/or dietary modification within the last 6 months * C-reactive protein (CRP) \> upper limit of normal (ULN) at the start of the most recent attack Exclusion Criteria: * Complicated diverticular disease * Right-sided diverticulitis * Previous colonic surgery * Presence of symptomatic organic disease of the gastrointestinal tract * Active colorectal cancer or a history of colorectal cancer * Hemorrhagic diathesis * Active peptic ulcer disease, local intestinal infection * Asthma if careful medical monitoring is not ensured * Abnormal hepatic function or liver cirrhosis * Abnormal renal function