Training-induced Cerebral Reorganization in Schizophrenia

University of Konstanz60 enrolled

Overview

The purpose of this study is to reveal the effects of computer-aided cognitive-auditory training on cerebral reorganization in schizophrenia.

Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease. In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing. The other training involves a variability of cognitive abilities. Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

SINGLE

Enrollment

Conditions

Schizophrenia

Interventions

Brain Fitness ProgramBEHAVIORAL

Computer-aided cognitive program designed for intensive training of auditory perception, memory and attention

CogpackBEHAVIORAL

Computer-aided cognitive program for cognitive abilities

Eligibility

Sex: ALLMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of schizophrenia and disorders with psychotic features * Intact hearing abilities Exclusion Criteria: * Mental retardation * Age over 60 * Insufficient German language knowledge

Locations (1)

University of Konstanz

Konstanz, Baden Württenberg, Germany

Outcomes

Primary Outcomes

Event related potential MEG, test scores in word fluency and verbal learning tasks

Time frame: pre and post intervention

Secondary Outcomes

Symptom severity, GAF score

Time frame: pre and post intervention

Data from ClinicalTrials.gov

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