Effect of Ondansetron for Withdrawal Symptoms

Stanford University31 enrolled

Overview

We hope to determine whether Ondansetron, an anti-nausea medication, works to help relieve withdrawal symptoms experienced while the patient is being weaned off opioid medications. This medication has shown anecdotal evidence of being affective for the treatment of withdrawal symptoms and we hope to determine whether this is affective.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Substance Withdrawal Syndrome

Interventions

Ondansetron and Placebo crossoverDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria:-Over 18 years of age * No medical contraindications to medication * Able to fulfill research procedures Exclusion Criteria:-Subjects who are unable to respond to our questionnaires or to stimuli as required by the experimental protocol will be excluded. * Subjects will be excluded if they have a history of significant psychiatric disorders that would prevent them from engaging in a treatment program. * Participating in other studies that would interfere with the procedures in this study * Known or apparent pregnancy

Locations (1)

Stanford University School of Medicine

Stanford, California, United States

Outcomes

Primary Outcomes

Change in Withdrawal Symptoms With Placebo and With Ondansetron

Subjective Opioid Withdrawal Scale: Participants were asked to rate, from 0 to 4, their experience of 15 withdrawal symptoms. Scores for each participant were derived from the sum of their withdrawal symptoms score (minimum:0, maximum: 60). A higher score indicates more symptoms experienced and/or at a greater degree of severity.

Time frame: Baseline, 1 hour post dose Placebo, 1 hour post dose Ondansetron

Data from ClinicalTrials.gov

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