Exploring the Effects of Diazepam and Lorazepam

University Hospital, Strasbourg, France22 enrolled

Overview

Aims : * exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI * comparing lorazepam effects to diazepam (0.3 mg/kg)effects * exploring benzodiazepines effects, after a single oral intake, on the neural correlates of successful encoding of information within explicit memory using fMRI Hypothesis : * both diazepam and lorazepam will impair explicit memory performance, but lorazepam only will impair perceptual priming * lorazepam and diazepam will modify the normal correlates of information encoding within explicit memory * lorazepam only will alter the neural correlates of perceptual priming

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Healthy Subjects

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy subjects between 18 and 30 years * Students in medicine, dentistry or pharmacy * French as a mother language Exclusion criteria: * Medical condition influencing brain function (neurological or psychiatric) * Asthma * General anesthesia in the 3 last months * Drug addiction (DSM IV criteria) * Regular medical treatment (except contraceptive pill) * Significant impairment observed during a medical examination including ECG * Intake of any psychotropic drug that can have a effect during testing * IQ (Wechsler) \< 100 * FMRI contra-indication (implantable magnetic material, claustrophobia) * Known allergy to benzodiazepine or lactose * \> 10 cigarettes/day * Pregnant or breast-feeding woman * No health insurance * Subjects who do not complete the entire study

Locations (2)

Centre d'investigation clinique, hôpital civil

Strasbourg, France

Clinique psychiatrique, hôpital civil

Strasbourg, France

Outcomes

Primary Outcomes

Exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI

Time frame: After a single oral intake

Secondary Outcomes

Comparing lorazepam effects to diazepam (0.3 mg/kg)effects

Time frame: After a single oral intake

Exploring benzodiazepines effects, after a single oral intake, on the neural correlates of successful encoding of information within explicit memory using fMRI

Time frame: After single oral intake