The Effects of Rasagiline on Cognitive Deficits Associated With Parkinson's Disease

Inclusion Criteria: 1. Male and female patients of any age 2. Diagnosis of Idiopathic PD according to the UK Brain Bank Criteria for the clinical diagnosis of PD. 3. Patients with cognitive impairment associated with PD, defined as: 1. Subjective complaints of impaired cognitive functions such as forgetfulness, word finding difficulties or inattentiveness 2. Presence of objectively demonstrable cognitive deficits in at least 2 out of the 4 cognitive domains typically impaired in PD. These include attention, executive functions, memory and visuo-spatial functions. The performance in the following test scores must be 1.5 standard deviations below the mean normative score for age and education of the patient: Digit Span for attention, Letter Fluency test for executive function, Logical Memory Sub-scale from the Wechsler Memory Scale-Revised and Line Orientation Test for visuo-spatial function. 4. Patients with a Hoehn and Yahr stage I-III when "on" 5. Literate patients who are able to follow test instructions Exclusion Criteria: 1. Diagnosis of dementia due to PD according to DSM IV criteria 2. Diagnosis of current major depressive episode according to DSM IV criteria 3. Presence of any other neurodegenerative disorder other than PD 4. Presence of any unstable or untreated systemic disorder such as diabetes, cardiac failure, renal failure 5. Use of any prohibited concomitant medication