We will study if small children who become ill with respiratory distress during the RSV epidemic are better relieved with salbutamol nebulizations diluted in hypertonic (3%), instead of normal (0.9%) saline.
In Santiago, Chile, a near collapse of health services is a notorious feature of every winter when vast numbers of small children line for attention because of respiratory distress caused by a probable RSV infection. Our study will examine if nebulized salbutamol diluted in hypertonic (3%), instead of normal (0.9%) saline, provides better relief in outpatients. If hypertonic saline proves safe and effective, the patients could be better managed and the pressure for attention diminished at a low cost, by a simple change in the saline ampule.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
74
The first of 3 nebulizations of 0.5 mg of Salbutamol is diluted in 3.5 ml of hypertonic (3%) saline. The second and the third are diluted in normal (0.9%) saline.
The 3 nebulizations of 0.5 mg of Salbutamol are diluted in 3.5 ml of normal (0.9%) saline.
Clínica Vespucio
Santiago, Chile
RECRUITINGChange in the respiratory distress score (Tal) between the basal score and the final score after 3 salbutamol nebulizations
Time frame: 1 hour
Change in the respiratory distress score (Tal) between the basal score and the first nebulization
Time frame: 15 to 20 minutes
Change in the respiratory distress score (Tal) between the basal score and the second nebulization
Time frame: 15 to 20 minutes after the first nebulization
Change in pulse oxymetry reading between the basal score and after each of the three nebulizations
Time frame: 1 hour
Change in cardiac frequency, irritability, general condition or anything else between the basal score and the first, second and third nebulization
Time frame: 1 hour
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