Radiotherapy Planning Based on Positron Emission Tomography With Fluoro-deoxyglucose For Advanced NSCLC

Inclusion Criteria: * histologically proved NSCLC * UICC-stage I-III, no resection planned * complete staging \< 6 wks before treatment including cranial CT * ECOG \<3, Karnofsky-Index \>60% * age \> 18 \< * FEV1 \> 1,0 l or \>35% * RT-planning according to protocol feasible * chemotherapy feasible * written informed consent Exclusion Criteria: * neuroendocrine tumors, plain broncho-alveolar-cell ca. * distant metastases, supraclavicular lymph node metastases * malignant pleural effusion * resection of actual tumor performed * inclusion in other study protocol * chemotherapy due to actual tumor before FDG-PET * induction-chemotherapy * acute vena cava superior syndrome * second malignancy other than basalioma * pregnancy, lactation * heart insufficiency NYHA III/IV * pneumoconiosis with active inflammatory changes of mediastinal lymph nodes * acute broncho-pulmonary infection at time of PET-examination