Dexmedetomidine Cardiovascular Safety in Pediatric Burn Patients

Inclusion Criteria: * pediatric patient * \>25% total body surface area (tbsa) burn and \< 90% tbsa * opioid requirements \> 0.1 mg/kg/hour of morphine (or equivalent) * midazolam requirement \> 0.1 mg/kg/hour * treatment team determined that patient should be started on dexmedetomidine Exclusion Criteria: * hemodynamically unstable patients (epinephrine \> 1.0 ug/kg/min, levophed \> 0.75 ug/kg/min, dopamine \> 10 ug/kg/min) * pregnant patients * patients with history of heart block * patients with congenital heart disease * patients with significant hepatic dysfunction * patients with urine output \< 0.5 ml/kg/hour \[averaged\] over past 24 hours