Humoral and Cellular Immune Response of Herpes Simplex (gD) Candidate Vaccines From 2 Different Cell Lines

Inclusion Criteria: * Between 18 and 45 years of age * Written informed consent * Female volunteers must be using contraception and should avoid becoming pregnant for the duration of the vaccination course * Serology: Groups 1, 3, 4 and 5: HSV-1 AND HSV-2 seronegative (by gD2 ELISA); Group 2: HSV seropositive by gD2 ELISA before entry Exclusion Criteria: * Any previous vaccination against Herpes simplex. * Any previous administration of MPL. * Pregnancy or lactation. * Patient is immuno-compromised or is receiving immuno-modifying therapy of any kind. * Clinical signs of acute or febrile illness at the time of entry into the study. * Any administration of immunoglobulins during the vaccination course or within one month of vaccination. * Any vaccination within one week of study vaccination. * Previous known hypersensitivity to vaccination or to any component of the vaccine. * Simultaneous participation in any other clinical trial with an investigational drug or vaccine. Subjects currently in a follow-up period of a vaccine study can be included. * Recent history of alcoholism or drug abuse (within the past 6 months). * Life-threatening or serious cardiac (NYHA grades III-IV), gastrointestinal, hepatic, renal, hematological or immunological disorder which, in the opinion of the investigator, would preclude entry into the study.