Evaluation of Safety of Candidate gD Vaccine, With or Without MPL in Healthy Herpes Simplex Virus-positive Adults

Inclusion Criteria: * Between 18 and 40 years of age * Seropositive for antibodies against HSV * Female volunteers must have been using contraceptives for at least 2 months before the entry and should avoid becoming pregnant for the duration of this study. * Good physical condition as established by physical examination and history taking at the time of entry Exclusion Criteria: * Any abnormal laboratory value among the tests performed at screening. * History of persistent hepatic, renal, cardiac or respiratory diseases * Clinical signs of acute illness at the time of entry into the study. * Previous history of asthma or hypersensitivity to drugs. * Seropositive for antibodies against the human immunodeficiency virus * Pregnancy and lactation. * Treatment with corticosteroids or immunomodulating drugs. * Simultaneous participation in another clinical trial. * Administration of any other vaccine or immunoglobulins during the study period