Matrifen® for Therapy of Severe Chronic Pain®

Patient's Assessment of Pain Severity Score

Assessment on a Visual Analogue Scale from 0=No pain to 10=Most severe pain

Time frame: Before and after therapy with Matrifen® (4 weeks)

Physician's Final Assessment of the Efficacy of Therapy With Matrifen®

Assessment on a scale: Excellent, good, satisfactory, dissatisfactory

Time frame: After 4 week therapy with Matrifen®

EQ-5D (Optional): Domain Mobility

This outcome measure to assess patients quality of life is based on an optional standardised patient questionnaire (EQ-5D). Questions on a scale from 1-3 at initial and final visit: 1. I have no problems in walking around 2. I have some problems in walking around 3. I am confined to bed

Time frame: Before and after therapy with Matrifen® (4 weeks)

EQ-5D (Optional): Domain Self Care

This outcome measure to assess patients quality of life is based on an optional standardised patient questionnaire (EQ-5D). Questions on a scale from 1-3 at initial and final visit: 1. I have no problems with self-care 2. I have some problems washing or dressing myself 3. I am unable to wash or dress myself

Time frame: Before and after therapy with Matrifen® (4 weeks)

EQ-5D (Optional): Domain Usual Activities

This outcome measure to assess patients quality of life is based on an optional standardised patient questionnaire (EQ-5D). Questions on a scale from 1-3 at initial and final visit: 1. I have no problems with performing my usual activities 2. I have some problems with performing my usual activities 3. I am unable to perform my usual activities

Time frame: Before and after therapy with Matrifen® (4 weeks)

EQ-5D (Optional): Pain / Discomfort

This outcome measure to assess patients quality of life is based on an optional standardised patient questionnaire (EQ-5D). Questions on a scale from 1-3 at initial and final visit: 1. I have no pain or discomfort 2. I have moderate pain or discomfort 3. I have extreme pain or discomfort