The Effect of Nexium and Probiotics on Insulin Secretion and Cardiovascular Risk Factors in Patients With Type 2 Diabetes

Inclusion Criteria: * Type 2 diabetes (WHO criteria) treated with metformin and/or sulfonylureas or diet * Males and females between 40 and 70 years * HbA1c between 6,0-10,0 * Diabetes duration \> 1 year Exclusion Criteria: * Kidney disease (s-creatinine above the upper limit of normal range). * Liver disease (ALAT increase \> 3 times the upper limit of the normal range of ALAT). * Macroalbuminuria (urinary albumin excretion of \> 300 mg/day). * Heart failure(NYHA class lll or lV) * Severe neuropathy (symptoms + vibration perception threshold \> 50 measured by biothesiometer.) * Neutropenia (neutrophil count\<2.0x10/l) or anemia (hemoglobin\<8mM for men or \<7mM for women. * Alcohol abuse * Drug abuse * Severe organic or metabolic diseases including cancer * C-peptide\< 0,3 pmol/l * Medicine interaction * Treatment with insulin * PPI or other medications for ulcus diseases * Treatment with warfarin or other coumarin derivations * Pregnant or breastfeeding women * Allergy to medication used in the study * Participants may not participate in another clinical intervention trial