Substrate Metabolism and Insulin Sensitivity in Patients With Hyperprolactinemia Before and After Treatment

University of Aarhus

Overview

The purpose of this study is to investigate the effects of chronic elevated levels of Prolactin on metabolism and insulin sensitivity by studying patients with hyperprolactinemia before and after treatment.

Study Type

OBSERVATIONAL

Conditions

Hyperprolactinemia Insulin Resistance

Interventions

CabergolineOTHER

Cabergoline 0,25 - 1,0 mg once a week, controlled by our outpatient clinic. The drug regimen is not influenced by participating in this study.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Written consent * Age between 18 and 70 * At diagnose a serum prolactin \> 200 microgram/l (10 U/l) Exclusion Criteria: * Hypothyroidism * Use of any medication * Pregnancy

Locations (1)

Department of Endocrinology

Aarhus C, Aarhus, Denmark

Outcomes

Primary Outcomes

Insulin sensitivity

Time frame: Before and after treatment

Secondary Outcomes

QoL, body composition, intrahepatic and intramyocellular fat, substrate metabolism, glucose tolerance

Time frame: Before and after treatment

Data from ClinicalTrials.gov

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