This study examines the effect of combined nicotine replacement therapy (transdermal patch + nasal spray vs. transdermal patch + placebo nasal spray) on reactivity to alcohol and self-administration behavior.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
22
21mg transdermal nicotine patch
two 0.5mg/sprays, one to each nostril (dose = 1mg) The nicotine nasal spray is formulated by the Investigational Drug Service at Yale-New Haven Hospital. It is similar in concentration to Nicotrol.
saline combined with capsaicin to mimic the brief nasal irritation from active nicotine spray The placebo nasal spray is formulated by the Investigational Drug Service at Yale-New Haven Hospital.
Connecticut Mental Health Center & Yale-New Haven Hospital
New Haven, Connecticut, United States
Number of Drinks Consumed During an Ad-libitum Drinking Period
Participants are presented with alcohol beverages and allowed to drink at their leisure.
Time frame: Two hour ad-libitum drinking period during laboratory session
Craving for Alcohol
Alcohol craving was measured using the Alcohol Urge Questionnaire (AUQ). The range of scores is 1-100 on a visual analog scale (VAS). Higher scores indicate higher levels of craving. Score indicated is the total score.
Time frame: first measurement during laboratory session (+60 minutes after beginning of laboratory session)
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