* To prove whether use of antiplatelet agents results into a rapid enlargement of hematoma after onset of acute intracerebral hemorrhage. * To prove the efficacy and safety of platelet transfusion for prevention of hematoma growth in patients who were stricken by acute intracerebral hemorrhage while being on antiplatelet medication.
* Hematoma growth is a well-known powerful determinant of mortality and poor outcome after intracerebral hemorrhage. * Some observations suggest that previous use of antiplatelet agents associates with rapid hematoma enlargement and poor outcome after cerebral hemorrhage. * Immediate platelet transfusion for such patients may prevent hematoma growth but also cause thromboembolic complications.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
100
Four units of fresh platelets will be infused immediately
Department of Neurology, Oulu University Hospital
Oulu, Finland
RECRUITINGHematoma growth within 24 h measured as increase in hematoma volume observed by head CT
Time frame: 24 hours
Glasgow Outcome Score
Time frame: 90 days
Cardiovascular death occurring within the treatment period
Time frame: 90 days
Death due to any cause occurring within the treatment period
Time frame: 90 days
Acute myocardial infarction
Time frame: 90 days
Venous thromboembolism
Time frame: 90 days
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