Feasibility Study of a Vaginal Ring for Delivery of TMC120 (Dapivirine)

Inclusion Criteria: * Female, 18-50 years, inclusive * Willing and able to provide written informed consent * HIV-uninfected and otherwise healthy * Willing to abstain from sexual activity and use of vaginal products while participating in the trial * Currently using oral contraceptives for pregnancy prevention * Willing to use oral contraceptives as needed to avoid menstruation while taking part in this trial Exclusion Criteria: * History of alcoholism, drug abuse, psychosis, antagonistic personality, poor motivation, or other emotional or intellectual problems that are likely to invalidate the informed consent process or adversely impact compliance with protocol requirements. * History of allergy to TMC120 or to the constituents of the vaginal ring. * History of hypersensitivity to propofol, or other contraindication to general anesthesia or sedation * History of diagnosis of and/or treatment for a sexually transmitted disease within the last three months. * History of genital tract surgery within the last month * Currently pregnant or breastfeeding, or within two months of last pregnancy outcome * Currently or within one month of participating in any other clinical research trial * Current (during screening) diagnosis of any genital infection * Current vulvar of vaginal symptoms * Current non-iatrogenic pelvic/colposcopic exam findings involving deep epithelial disruption