Botulinum Toxin for Carpal Tunnel Syndrome

University of Minnesota

Overview

To compare local steroid injections to local Botulinum toxin A injection in a double-blinded study.

To compare local steroid injections to local Botulinum toxin A injection in a double-blinded study. The goal is to investigate if Botulinum toxin A injections are effective for Carpal Tunnel Syndrome compared to steroid injections in terms of pain relief and length of symptom alleviation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Conditions

Carpal Tunnel Syndrome

Interventions

Botulinum toxinDRUG

45 units Botox injected into Carpal Tunnel once

Corticosteroid injection into Carpal TunnelDRUG

40 mg Triamcinolone with one mL 1% lidocaine injected once into Carpal Tunnel

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Any individual with symptoms of carpal tunnel syndrome and a diagnosis of CTS either clinically or via EMG will be included into this study. There will be a total of 20 subjects displaying symptoms of CTS. The gender of the subjects will not determine enrollment. There is no requirement of male to female ratio for this study. There is no age cut-off or minimal age requirement to enroll in the study. No specific Racial or ethnic restrictions will be present for this study. Female subjects of childbearing potential (not surgically sterile or postmenopausal for at least 2 years) must have a negative pregnancy test at screening. Exclusion Criteria: 1. Any individual who has a diagnosis of CTS (by EMG or other means) but no symptoms of CTS will be excluded from this study. 2. Vulnerable subjects as defined as children, pregnant women, those with limited autonomy, decisional incapacity and prisoners will not be enrolled in this study. 3. Individuals with any history of carpal tunnel release surgery and recurrent or persistent symptoms will be excluded form this study. 4. Subject is pregnant or lactating.

Locations (1)

University of Minnesota PM&R Department

Minneapolis, Minnesota, United States

Outcomes

Primary Outcomes

Visual Analog Scale

Time frame: one week, one month, three months, six month, nine months, and twelve months

Secondary Outcomes

Carpal Tunnel Syndrome Assessment Questionnaire

Time frame: one week, one month, three months, six month, nine months, and twelve months

Data from ClinicalTrials.gov

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