The study evaluates 3 different populations: It is an open, randomized, parallel-group study comparing the effectiveness of intravenous (iv) ajmaline with currently used antiarrhythmic drugs in the acute treatment of : 1. recent-onset atrial fibrillation versus iv flecainide 2. sustained monomorphous ventricular tachycardia versus iv procainamide The study also evaluates in an open, randomized, crossover study, the use of iv ajmaline versus iv flecainide in the diagnosis of Brugada syndrome
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
123
2 mg/kg iv in 10 minutes
1 mg/kg iv in 10 minutes
10 mg/kg iv in 10 minutes
Servicio de Cardiología, Hospital Clínic
Barcelona, Barcelona, Spain
Hospital Donostia
Donostia / San Sebastian, Guipuzcoa, Spain
Hospital Puerta de Hierro
Madrid, Madrid, Spain
Hospital La Fe
Valencia, Valencia, Spain
Proportion of patients with reversion of atrial fibrillation
Time frame: 1 hour
Proportion of patients with reversion of ventricular tachycardia
Time frame: 15 min
Proportion of subjects developing EKG pattern diagnostic of Brugada Sd. after provocation test.
Time frame: 1 hour
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