Immunoregulation of Periodontal Disease

Assistance Publique Hopitaux De Marseille23 enrolled

Overview

Our design is to test in hospital practice a selection of immune parameters that could assess the pathophysiology and progression of periodontal lesions.

These parameters will be measured in 25 healthy volunteers and 25 moderate-to severe periodontal disese patients. Phagocytes will be tested phenotypically and functionally, both ex vivo and in vitro.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Periodontal Disease

Interventions

Blood samplingOTHER

Analysis of the PNN, analysis of the monocytes

Blood samplingOTHER

Analysis of the PNN, analysis of the monocytes

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Persons appearing spontaneously at the consultation of parodontologie for parodontale disease, * persons agreeing to undergo a sampling of blood intended for the search Exclusion Criteria: * Presence of a chronic or pointed pathology, * an age 18-year-old subordinate or 65-year-old superior, * pregnant women,

Locations (1)

Hopital de la Conception- Laboratoire d'Immunologie

Marseille, France

Outcomes

Primary Outcomes

Percentage of positive cells and intensity of expression for the molecules of surface studied there cytometric in stream

Time frame: 24 months

Secondary Outcomes

Rate of secretion of cytokines and the other substances

Time frame: 24 months

Detection and quantification of ARN messengers

Time frame: 24 months

Data from ClinicalTrials.gov

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