Effects of Inhaled Treprostinil Sodium for the Treatment of Pulmonary Hypertension Associated With Idiopathic Pulmonary Fibrosis

Inclusion Criteria: * 35 to 80 years of age * Male or female * Diagnosis of IPF 1. Investigator diagnosis based on history, physical examination, HRCT,and pulmonary function testing 2. Clinical symptoms of IPF for at least three months prior to Visit 1 3. High Resolution CT scan showing definite or probable IPF (any time in the past). Bibasilar reticular abnormalities with minimal ground glass opacities on HRCT scan must also be present (at any time in the past) 4. Surgical lung biopsy showing usual interstitial pneumonia, or transbronchial lung biopsy that was not diagnostic of an alternative condition. For patients younger than 50 years, a surgical lung biopsy is required (at any time in the past) 5. FVC ≥ 30 % and \< 70% of predicted value within three months prior to Visit 1 6. DLCO ≥ 15% and \<70% of predicted value within three months prior to Visit 1. * Diagnosis of PH 1. Previously documented radiographic or echocardiographic findings suggestive of pulmonary hypertension 2. Prior right heart catheterization diagnostic of pre-capillary pulmonary hypertension. \[The presence of pre-capillary pulmonary hypertension will be verified by right heart catheterization during Study Visit 3, before enrollment and administration of study drug\]. * No changes in concomitant medications prescribed to treat PAH or IPF for 30 days to Visit 1 * Females of childbearing potential may participate only if they are not currently pregnant or lactating and are either one of the following: 1. Surgically sterile 2. At least 1 year post-menopausal 3. Practicing an acceptable method of birth control for at least 30 prior to the Visit 1 with plans to continue this method for the duration of their participation in the study. * An echocardiogram will be performed at Visit 2. Only those subjects with Visit 2 echocardiographic findings that strongly suggest the presence of pulmonary hypertension, will proceed to Visit 3. Acceptable findings include any of the following: 1. TR velocity greater than 3.5 m/sec 2. TR velocity greater than 3.0 m/sec with right ventricular enlargement or dysfunction * A right heart catheterization will be performed at Visit 3. Only those subjects with Visit 3 right heart catheterization findings that establish the presence of pulmonary hypertension will proceed to enrollment and study drug administration. Acceptable findings must include all of the followings: 1. mean PA pressure equal or greater than 25 mm HG 2. pulmonary capillary wedge pressure equal or less than 15 mm Hg 3. pulmonary vascular resistance greater than 3 mmHg/min Exclusion Criteria: A subject will not be eligible for inclusion in this study if ANY of the following criteria apply: * History of known or suspected pulmonary embolism or deep venous thrombosis * Clinical evidence of left-sided heart disease * Presence of atrial fibrillation (determined from 12 lead ECG at Visit 1 or 2) * Other medical condition or drug exposure known to be associated with pulmonary fibrosis (e.g., rheumatoid arthritis, lupus, scleroderma, etc.) or pulmonary arterial hypertension (e.g., connective tissue disease, congenital heart disease, portal hypertension, HIV infection, drug and toxins, etc.) * Upper or lower respiratory infection within 30 days prior to Visit 1 * Hospitalization for respiratory illness within 30 days prior to Visit 1 * Diagnosis of any other clinically significant illness that, in the opinion of the investigator, might put the subject at risk of harm from participation in the study or might adversely effect the interpretation of the study data. (e.g., significant liver or kidney disease, etc.) * History of recurrent symptoms that might, in the opinion of the investigator, adversely effect the interpretation of the study data (e.g., severe headaches, diarrhea, jaw pain, syncope, nausea,vomiting, etc.) * Current treatment with any medication that is approved by the US FDA to treat pulmonary hypertension (e.g., epoprostenol(Flolan), treprostinil (Remodulin), iloprost (Ventavis), bosentan(Tracleer), ambrisentan (Letairis), sildenafil (Revatio), etc.,), or tadalafil (Cialis) * Current treatment with an anticoagulant * A reactive screen for hepatitis B surface antigen, or the hepatitis C antibody, or HIV antibody as tested at Visit 1. * Use of any inhaled tobacco products or significant history of drug abuse within 90 days prior to Visit 1 * The subject has an echocardiogram performed at Visit 2 that demonstrate findings that are indicative of left ventricular or valvular disease. Findings that will be considered evidence of left ventricular or valvular disease, and therefore exclude the subject from proceeding to Visit 3 are any of the following: 1. LVEF \< 55% 2. Moderate to Severe mitral regurgitation or aortic regurgitation 3. Any mitral stenosis or aortic stenosis 4. Grade 2 or 3 diastolic dysfunction by Doppler * Use of any investigational drug, or participation in any investigational study within the 30 days prior to Visit 1.