The purpose of this study was to study the effect of different combinations of fenofibrate and coenzyme Q10 on ventricular diastolic function in patients with Type II diabetes
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
278
Fenofibrate pbo/CoQ10 placebo
Fenofibrate pbo/CoQ10 200 mg
Fenofibrate 160mg/CoQ10 placebo
Site 002
Fremantle, Australia
Site 003
Nedlands, Australia
Site 001
Perth, Australia
Evolution of the E'/E septal ratio
Time frame: End of study (V6)
Severity of the LVDD
Time frame: End of study (V6)
Evolution of the Left atrium and right atrium volumes
Time frame: End of study (V6)
Evolution of the Left and right sizes
Time frame: End of study (V6)
Evolution of the LVEDD and LVESD
Time frame: End of study (V6)
Evolution of the LVEDV and LVESV
Time frame: End of study (V6)
Evolution of the LV mass
Time frame: End of study (V6)
Evolution of the LV ejection fraction
Time frame: End of study (V6)
Evolution of the IVRT
Time frame: End of study (V6)
Evolution of the tissue Doppler E'/A' ratio
Time frame: End of study (V6)
Evolution of the PV doppler parameters
Time frame: End of study (V6)
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Fenofibrate 80/CoQ10 100 mg
Fenofibrate 160mg/CoQ10 100 mg
Fenofibrate 80 /CoQ10 200 mg
Fenofibrate 160mg/CoQ10 200 mg