Quality of Life for Subjects Receiving Androgen Deprivation Therapy and Have a Doubling in PSA of Either Less Than or Greater Than 1 Year

Inclusion Criteria: * 18 years or older * Received therapy of curative intent (surgery or radiotherapy) * Have a rising PSA which has doubled from a nadir value. * Histologically proven prostate cancer requiring androgen deprivation therapy for at least 12 months * Written informed consent to participate in the trial. Exclusion Criteria: * Known hypersensitivity to Zoladex, Casodex, ar any component of these products * Prior treatment with LHRH agonist or anti-androgens in the past 12 months * Any concomitant condition that would make it undesirable, in the physician's opinion, for the subject to participate in the trial or would jeopardize compliance with the protocol.