Durability of Nevirapine-Based Antiretroviral Regimen

Bamrasnaradura Infectious Diseases Institute140 enrolled

Overview

Although nevirapine is used as an alternative to efavirenz for initial regimen in developed countries, nevirapine has still been a key antiretroviral drug in many resource-limited countries including Thailand due to its accessibility and affordability. In addition, a component of stavudine and lamivudine is still widely used as a backbone in the antiretroviral regimen in this setting.To date, data on the durability of a regimen of stavudine, lamivudine and nevirapine are very limited, particularly from the resource-limited settings.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

140

Conditions

HIV Infections

Interventions

nevirapineDRUG

200 mg/day twice a day

Eligibility

Sex: ALLMin age: 15 Years

Medical Language ↔ Plain English

Inclusion Criteria: * HIV-infected individuals ≥15 years of age * CD4 cell count \<350 cells/mm3 * Willing to participate and give consent form Exclusion Criteria: * previous antiretroviral therapy * pregnancy * receiving a medication that has drug-drug interactions with NVP or RFP * aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \>5 times of upper limit of normal range

Locations (1)

Department of Medicine, Bamrasnaradura Infectious Diseases Institute

Nonthaburi, Changwat Nonthaburi, Thailand

Outcomes

Primary Outcomes

number of patients with undetectable plasma HIV-1 viral load

Time frame: 240 weeks

Data from ClinicalTrials.gov

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