Does Simvastatin Affect Insulin Sensitivity in Dyslipidemic Type 2 Diabetic Patients?

Inclusion Criteria: * Type 2 diabetic patients with known duration of disease: 3-10 years * Age: 35-75 years * BMI\<32 kg/m2 * Hypercholesterolemia: fasting serum low density lipoprotein (LDL) * Cholesterol concentration \< 4.16 mmol/L (\<160 mg/dl) * Normotriglyceridemia: fasting plasma triglyceride concentration \< 2.75 mmol/L (250 mg/dl) * Creatinine levels \< 1.8 mg /dl * Liver transaminases \< 20% over the upper limit with no active liver disease and CK \< 50% above the upper limit * Blood pressure less than 160/100 mmHg were accepted as eligible for enrollment Exclusion Criteria: * Hypertension, cardiovascular disease or metabolic diseases other than T2DM as determined by medical history, physical examination and routine laboratory tests * Alcohol consumption (more than 10 drinks/week) * Poor glycemic control (HbA1c\<9%) * Patients requiring insulin, patients with type 1 diabetes * Patients taking any medicine known to interfere with metabolism of statins or with insulin sensitivity as summarized in an exclusionary drug table * Patients receiving any hypolipidemic medication or diet during the last 2 months before enrollment