The purpose of this study is to determine whether coronary artery CT scanning or nuclear stress testing is better at diagnosing chest pain patients with coronary artery disease to select appropriate candidates for coronary catheterization and re-vascularization.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
400
64-detector, retrospectively EKG-gated, computed tomography angiography of the coronary arteries during heart rate control (intravenous metoprolol, when necessary)
Usually dual-isotope perfusion imaging at rest (201-Thallium) and at stress (99m-Technetium-MIBI). Some patients will have a 2-day MIBI protocol. Gated SPECT and attenuation-correction images will be obtained. Treadmill stress will be performed. If a patient is unable to exercise, adenosine or dobutamine will be given.
Moses Division, Montefiore Medical Center
The Bronx, New York, United States
Coronary catheterization that does not lead to re-vascularization
Time frame: 1 year
Length of Hospital Stay (time to discharge)
Time frame: usually from hours to a few days (average about one day)
Non-fatal myocardial infarction
Time frame: 1 year
Death (all cause)
Time frame: 1 year
Post-test renal dysfunction
Time frame: usually within a few days
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