Multidetector Raw CT as a Single Tool in the Setting of Ischemic Stroke

Hospices Civils de Lyon49 enrolled

Overview

This is a prospective study including acute ischemic stroke patients aged 18 to 90. Multidetector raw CT is performed in acute ischemic stroke patients. Heart, neck vessels and brain arteries are studied during the same acquisition. Results are compared with the standard methods including transesophageal echocardiography (TEE), Doppler ultrasound (DUS) and MR angiography (MRA) of neck vessels. The main criteria is the ability of CT to classify the stroke etiology correctly according to the TOAST classification in comparison with the standard methods.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Ischemic Stroke

Interventions

Multidetector raw CTDEVICE

Multidetector raw CT

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Acute (\< 1 week) ischemic stroke patient aged 18 to 90 * Informed consent obtained * Presence of health insurance Exclusion Criteria: * Pregnancy or absence of efficient contraceptive method * Allergy * Allergy to contrast material * Asthma * Renal failure (blood creatinine \> 130 µmoles/l, creatinine clearance \< 80 ml/mn according to Cockroft method) * Myeloma * Hyperthyroidism (uncontrolled) * Difficulties to synchronize CT to heart rhythm * Contra-indication to TEE or MRI * Absence or retirement of informed consent * Absence of health insurance

Locations (1)

Hôpital Cardiologique Louis Pradel

Bron, France

Outcomes

Primary Outcomes

Ability of CT to classify the stroke etiology correctly (TOAST classification) in comparison to reference methods (MRA, DUS, TEE)

Time frame: classify the stroke etiology

Secondary Outcomes

Ability of CT to detect the source of stroke in each etiological group. Reliability of CT in quantitative measures of artery stenosis, aortic atheroma, heart thrombus, heart tumors). Tolerance of CT

Time frame: detect the source of stroke

Data from ClinicalTrials.gov

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