An Open Study Comparing the Effects of Moxaverine on Ocular Blood Flow in Patients With Age- Related Macular Degeneration, Primary Open Angle Glaucoma and Healthy Control Subjects

Inclusion Criteria: * Men and women aged over 50 years * Ametropia of less than 6 diopters and anisometropia of less than 2 diopters * Clear non-lenticular ocular media AMD patients: * Patients with nonexudative AMD * Visual acuity in the study eye \> 20/60 Glaucoma patients: * Unilateral or bilateral primary open angle glaucoma * At least 3 reliable visual field testings * Treated intraocular pressure \< 21 mmHg, * Visual field mean deviation MD \<10 (Humphrey 30-2) Healthy control subjects: * Age- , gender- and sex- matched to the two patient groups, * Matched with regard to smoking habits of the two patient group * No observable eye diseases Exclusion Criteria: * History or presence of gastrointestinal, liver or kidney disease, or other conditions known to interfere with distribution, metabolism or excretion of the study drug * Blood donation during the previous 3 weeks * Abuse of alcoholic beverages or drugs, participation in a clinical trial in the 3 weeks preceding the study * Known diabetes mellitus * Presence of any ocular pathology that interferes with the aims of the present study * Intraocular surgery within the last 3 weeks * Hypersensitivity to moxaverine * Acute gastric bleeding, massive cerebral hemorrhage related to stroke