Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm

University of Vermont8 enrolled

Overview

This research is being conducted to help us better understand what causes exercise induced asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and adenosine, play an important role. The investigators will be measuring these chemicals in the exhaled breath of volunteers with exercise induced asthma as they undergo a test to mimic exercise induced asthma. The investigators will determine how the levels of these chemicals change in association with how lung function changes before, during and after an episode of exercise induced asthma.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Asthma, Exercise Induced

Interventions

Hyperpnea challengePROCEDURE

5 minutes of dry air hyperpnea to induce bronchospasm

Eligibility

Sex: ALLMin age: 12 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Physician diagnosed asthma * Age 12-75 yrs * FEV1 \> 70% predicted * HIB response \> 10 % * No smoking last 6 mo and \< 10 pack yrs * No URI last 4 weeks * No asthma exacerbation last 4 weks * Able to withhold SABA \> 8 hrs and LABA \> 24 hrs Exclusion Criteria: * Other lung disease * Cardiac disease or other condition that would preclude safe participation, on theophylline or leukotriene modifiers

Locations (1)

Vermont Lung Center

Colchester, Vermont, United States

Outcomes

Primary Outcomes

Change in level of cystLTs and adenosine

Time frame: Before and after hyperpnea challenge

Secondary Outcomes

Change in pH of EBC and change in pulmonary function

Time frame: Before and after hyperpnea challenge

Data from ClinicalTrials.gov

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