Study Comparing the Efficacy and Safety of ABT-874 to Etanercept and Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis

Phase 3CompletedNCT00710580

AbbVie (prior sponsor, Abbott)350 enrolled

Overview

Compare the efficacy of ABT-874 versus etanercept in subjects with moderate to severe plaque psoriasis

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

350

Conditions

Moderate to Severe Plaque Psoriasis

Interventions

ABT-874BIOLOGICAL

SQ injection 200 mg Weeks 0 and 4; 100 mg Week 8

etanerceptBIOLOGICAL

SQ injection 50 mg BIW

placeboDRUG

SQ placebo injections for ABT-874 and etanercept

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of Psoriasis for 6 MO * BSA 10% * PASI 12 or above * PGA 3 or above Exclusion Criteria: * Previous exposure to either etanercept or ABT-874

Locations (42)

Outcomes

Primary Outcomes

Proportion of subjects who achieve a PGA of 0 or 1 response relative to baseline at Week 12

Time frame: 12 Weeks

Proportion of subjects who achieve a PASI 75 response relative to baseline at Week 12

Time frame: 12 Weeks

Secondary Outcomes

Proportion of subjects who achieve a PASI 100 response relative to baseline at Week 12

Time frame: 12 Weeks

Data from ClinicalTrials.gov

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Site Reference ID/Investigator# 9984

Birmingham, Alabama, United States

Site Reference ID/Investigator# 10605

Birmingham, Alabama, United States

Site Reference ID/Investigator# 10001

Scottsdale, Arizona, United States

Site Reference ID/Investigator# 10502

Little Rock, Arkansas, United States

Site Reference ID/Investigator# 9985

Bakersfield, California, United States

Site Reference ID/Investigator# 10661

Irvine, California, United States

Site Reference ID/Investigator# 14701

Los Angeles, California, United States

Site Reference ID/Investigator# 9785

San Diego, California, United States

Site Reference ID/Investigator# 10662

Santa Monica, California, United States

Site Reference ID/Investigator# 10642

Vallejo, California, United States

...and 32 more locations