The purpose of this study is to determine how the body breaks down and excretes the investigational drug, AZD5672.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
4
single dose 200mg aqueous solution
Research Site
Macclesfield, Cheshire, United Kingdom
total radioactivity in plasma, whole blood, faeces and urine.
Time frame: Pre-dose, post dose, 0.25h, 0.5h, 0.75h, 1h, 1.5h, 2, 3, 4, 6, 9, 12, 24, 48, 72, 96, 120, 144, 168, 192, 216, 240h
Additional metabolite identification
Time frame: 0.5h, 3h, 6h, 12h, 24h
general safety assessments: AE reporting, physical examination, ECG, safety haematology and clinical chemistry assessment, vital signs
Time frame: Screening, pre-dose, Visit 2 (residential period) and visit 3 follow up
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