Efficacy of Thymosin alpha1 for Severe Sepsis

Inclusion Criteria: * Severe sepsis according to ACCP/CCM criteria * Patient or legally authorized representative able to provide informed consent Exclusion Criteria: * Subject is less than 18 years or more than 85 years of age * If female, the subject is pregnant or nursing * Subject is receiving immunosuppressive therapy such as cyclosporine, azothioprine,or cancer-related chemotherapy * Patient not expected to survive 28 days because of uncorrectable medical condition, such as poorly controlled neoplasm or other end-stage disease * History of bone marrow, lung, liver, pancreas, or small-bowel transplantation * Acute pancreatitis with no established source of infection