Comparative Study of Aripiprazole and Olanzapine in the Treatment of Patients With Acute Schizophrenia

Inclusion Criteria: * Patients with DSM-IV diagnosis of schizophrenia patients in acute relapse * Treated as outpatients for at least one continuous 3-month period during the past 12 months * PANSS total score ≥60 * Previously responsive to neuroleptics (other than clozapine) * Able to give informed consent and comprehend and satisfactorily comply with the protocol requirements Exclusion Criteria: * An Axis I (DSM-IV) diagnosis of schizoaffective disorder * A clinical picture and/or history that was consistent with: (a) Delirium, dementia, amnestic or other cognitive disorders; (b) Bipolar disorder; (c)personality disorder * Nonresponsive to prior olanzapine therapy * Likely to require prohibited concomitant therapy * DSM-IV criteria for any significant substance abuse within the past three months, including addiction to cocaine or alcohol * Known to be allergic or hypersensitive to study drugs * Represented a significant risk of committing suicide based on history or mental status exam * Unstable thyroid pathology and treatment within the past six months * A history or evidence of a medical condition that would expose the patient to an undue risk * Clinically significant abnormal laboratory test results (including urine drug screen), vital sign, or ECG findings