Pharmacokinetic Interaction Between AZD3480 and Donepezil

Inclusion Criteria: * Provision of informed consent prior to any study-specific procedures * BMI between 18 and 30 kg/m2 * Medical and surgical history and physical examination without any clinically significant findings * Genotyped as an EM, defined in this study as having ≥ 1.5 functional CYP2D6 alleles, or a PM, defined as having zero functional CYP2D6 alleles Exclusion Criteria: * History of clinically significant cardio- or cerebrovascular, pulmonary, renal, hepatic, neurological, mental or gastrointestinal disorder or any other major disorder that may interfere with the objectives of the study, as judged by the Investigator * Clinically significant illness as judged by the Investigator, within two weeks before the first administration of investigational product * Female subjects who have a positive pregnancy test or who are pregnant or breast-feeding